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Terveyttä ruoasta! -materiaalit
Oulun yliopiston väitöskirjat
Autoimmunization against collagen XVII in patients with high risk for bullous pemphigoid and the effect of vildagliptin on the mouse skin proteome
Kieli:
englanti
Kustantaja:
Oulun yliopisto
Laitos:
Faculty of Medicine
Painosvuosi:
2024
Sidosasu:
pehmeäkantinen
Sijainti:
Print Tietotalo
Tekijät:
Nätynki, Antti
21.00 €
Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by intense itching and tense fluid-filled bullae and erythema located typically on the trunk and extremities. BP affects mainly patients over 70 years of age and has up to 40% two-year mortality. IgG autoantibodies against collagen XVII or BP180, a protein essential for dermo-epidermal junction structure, are demonstrated to be central in the pathogenesis of BP. Dermatitis herpetiformis (DH), an autoimmune dermatosis of patients with celiac disease (CD), and the use of dipeptidyl peptidase-4 inhibitors (DPP 4is or gliptins), drugs to treat type 2 diabetes (T2D), markedly increase the risk of BP. However, it is currently not clear how these conditions promote the development of BP. This study aimed to clarify the mechanisms
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