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Oulun yliopiston väitöskirjat

ASSOCIATION OF ADOPTIVE FAMILY FUNCTIONING AND GENETIC LIABILITY FOR BROAD SCHIZOPHRENIA SPECTRUM DISORDERS WITH ADOPTEES’ PSYCHIATRIC MORBIDITY ACTA UNIVERSITATIS OULUENSIS D Medica 1715


ISBN-13:978-952-62-3636-0 
Kieli:englanti 
Kustantaja:Oulun yliopisto 
Painosvuosi:2023 
Sidosasu:pehmeäkantinen 
Sivumäärä:152 
Tekijät:Toni Myllyaho 

25.00 €

Earlier research has solidified the role of genetic contributions in the etiology of schizophrenia and other psychiatric disorders. However, complex socio-environmental factors have also long been recognized to have an influence on the processes leading to the onset of psychiatric disorders. According to the vulnerability-stress model, the interaction of biological and environmental risk factors is suggested to play a key part in the development of psychiatric disorders. The study used data from the Finnish Adoptive Family Study of Schizophrenia. The data comprises adoptive families with adoptees who were, by their biological mother, at high (HR) and low (LR) genetic risk for broadly defined schizophrenia spectrum disorders. The ultimate purpose of this doctoral dissertation was to examine the impacts of HR for broad schizophrenia spectrum disorders and family-related environmental factors on the psychiatric morbidity of the adoptees. The environmental factors included duration of preadoption out-of-home care, adoptive family functioning, death and divorce of adoptive parents occurring before the offspring reached the age of 18, and socioeconomic status (SES) of adoptive families. The findings showed that among adoptees with longer time in preadoption out-of-home care (> 6 months), an increased risk for later psychiatric disorders was observed in the HR adoptees. Contrarily, among adoptees with shorter time in preadoption out-of-home care (≤ 6 months), later psychiatric disorders associated with adoptive family functioning. The findings also showed that the likelihood for psychiatric disorders was increased in adoptees raised in adoptive families with dysfunctional processes, especially among the HR adoptees. Furthermore, the findings indicated that dysfunctional family processes and HR for broad schizophrenia spectrum disorders were related to increased likelihood of psychiatric disorders of the adoptees only in families with high SES. In conclusion, the results imply that dysfunctional family processes and HR for broad schizophrenia spectrum disorders may increase the likelihood for psychiatric disorders in offspring both independently and in interaction. Furthermore, the results support the significance of familial SES and early caregiving circumstances in the development of psychiatric disorders. Keywords: family functioning, gene-environment interaction, genetic risk, preadoption out-of-home care, psychiatric disorders, schizophrenia, socioeconomic status

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