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Oulun yliopiston väitöskirjat

MICROSCOPIC COLITIS:CLINICAL FEATURES AND GASTRODUODENAL AND IMMUNOGENETIC FINDINGS, ACTA UNIVERSITATIS OULUENSIS D Medica 1097

ISBN-13:	978-951-42-9414-3
Kieli:	englanti
Kustantaja:	Oulun yliopisto
Laitos:	Lääketieteellinen tiedekunta
Oppiaine:	Lääketiede,farmasia
Painosvuosi:	2011
Sidosasu:	pehmeäkantinen
Sijainti:	Print Tietotalo
Sivumäärä:	156
Tekijät:	KOSKELA RITVA

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The aims of this study were to investigate the clinical features, the endoscopic and histologicalabnormalities of ileocolonic and gastroduodenal mucosa and immunogenetic background ofmicroscopic colitis (MC) and its subtypes collagenous colitis (CC) and lymphocytic colitis (LC).30 patients with CC and 54 with LC were examined with different control groups used accordingto the study. The mean age at diagnosis was in the sixties in both CC and LC, with a female preponderancein both Autoimmune conditions such as celiac diseased (CD) were common in MC. Bronchialasthma associated with LC. Lactose intolerance associated with MC but colonic diverticulosis wasrare. Ileal histological changes were common in MC. Focal gastritis did not associate with MC.Lymphocytic gastritis was found only in LC. Gastric endoscopic erosions were more prevalent inCC than in LC. The age at diagnosis of MC was higher in H. pylori positive than negative patients.The patients with MC had shorter duodenal villi than controls even when patients with CD were excluded. HLA-DR3-DQ2 haplotype and TNF2 allele carriage were more frequent in patients with MCcompared to controls. The genotype GG of IL-6-174 was more prevalent in MC compared to thecontrols. IL-6 genotype did not associate with the serum IL-6 concentration. The concentration ofIL-6 was higher in patients with CC than in LC. In conclusion, in addition to colonic typical inflammation, histological abnormalities weredetected also in gastric, duodenal and ileal mucosa. CD was common in MC, but there was noassociation with specific types of gastritis. HLA association was found in MC. Polymorphism inthe proinflammatory IL-6-174 gene displayed a possible association with MC. Although CC andLC share many clinical features, the differences in the occurrence of immune conditions, gastricabnormalities and IL-6 response point to differences in their pathogenesis.

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